BOSTON -- The Toronto Blue Jays used a pair of home runs to tie the game and then take the lead from the Boston Red Sox on their way to 7-3 win Saturday night at Fenway Park.

With Toronto trailing by two runs with two outs in the sixth, Edwin Encarnacion's two-run homer off Boston right-hander Aaron Cook tied it at 3-3. It was Encarnacion's 26th home run of the season.

Leading off the seventh, J.P. Arencibia's 14th home run put Toronto ahead.

The Jays added two more runs in the inning. With one out, Yunel Escobar reached on third baseman Will Middlebrooks' fielding error, ending Cook's outing.

Entering the game, Cook had given up just two home runs in 29 2/3 innings this season. He gave up that many in a span of three batters, recording just one out.

Franklin Morales replaced Cook and struck out Travis Snider and walked Rajai Davis before giving way to right-hander Matt Albers. Brett Lawrie's single to left scored Escobar and Davis, giving Toronto a 6-3 lead.

Jarrod Saltalamacchia, making his first start for Boston since Tuesday, hit a three-run home run into the visitors' bullpen in second inning off Carlos Villanueva.

Saltalamacchia's home run ended an 0-for-14 stretch. The catcher had been out of the starting lineup the previous three games. Manager Bobby Valentine said he preferred backup Kelly Shoppach to play against left-handers, whom the Sox faced in three straight games.

The Blue Jays cut their deficit in the third against Cook. Kelly Johnson led off with a double and Escobar reached on shortstop Pedro Ciriaco's error. A single by Travis Snider loaded the bases with no outs. After Anthony Gose struck out, Lawrie's sacrifice fly scored Johnson.

Toronto added a run in the ninth off Junichi Tazawa when Davis led off with a double off the left-field wall, took third on Lawrie's sacrifice bunt and scored on Colby Rasmus' fielder's choice.

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NOTES: Arencibia entered Saturday's game batting .367 over his past 10 games, with three doubles, two home runs, and six RBI in that span. ... Toronto right-hander Jason Frasor was placed on the 15-day disabled list Saturday with tightness in his right forearm. He is scheduled to undergo an MRI on Monday with Dr. James Andrews. ... Lawrie was back in the Toronto lineup Saturday after missing a game. Lawrie suffered a contusion on his right leg at Yankee Stadium on Wednesday attempting a diving catch on a foul ball. X-rays on Wednesday were negative. ... Center fielder Jacoby Ellsbury was not in the lineup for the Red Sox. Ellsbury missed 79 games with a subluxation of his right shoulder before being activated July 13. Valentine said Ellsbury was given the day off for medical reasons and may need occasional time off for the rest of the season. ... Shortstop Mike Aviles was also out of the starting lineup. Valentine said Aviles had "a little bit of turf toe." ... Boston's Daniel Nava played right field for the first time in his big-league career, spanning 119 games. ... Cody Ross served as the designated hitter for the first time in his nine-year career. ... The Red Sox held a pregame ceremony honoring Jason Varitek, who retired before the season after a 15-year career with the organization. ... Boston right-hander Daisuke Matsuzaka, on the disabled list since July 3 with a right upper trapezius strain, threw before the game. Valentine said Matsuzaka is "feeling better but not ready to face hitters yet."